Discrete phylogeographic models enable the inference of the geographic history of biological organisms along phylogenetic trees. Frequently applied in the context of epidemiological modelling, phylogeographic generalised linear models were developed to allow for the evaluation of multiple predictors of spatial diffusion. The standard phylogeographic generalised linear model formulation, however, assumes that rates of spatial diffusion are a noiseless deterministic function of the set of covariates, admitting no other unobserved sources of variation. Under a variety of simulation scenarios, we demonstrate that the lack of a term modelling stochastic noise results in high false positive rates for predictors of spatial diffusion. We further show that the false positive rate can be controlled by including a random effect term, thus allowing unobserved sources of rate variation. Finally, we apply this random effects model to three recently published datasets and contrast the results of analysing these datasets with those obtained using the standard model. Our study demonstrates the prevalence of false positive results for predictors under the standard phylogeographic model in multiple simulation scenarios and, using empirical data from the literature, highlights the importance of a model accounting for random variation.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/25651 |
| Date | January 2017 |
| Creators | Wolff-Piggott, Timothy |
| Contributors | Lacerda, Miguel, Murrell, Ben |
| Publisher | University of Cape Town, Faculty of Science, Department of Statistical Sciences |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Master Thesis, Masters, MSc |
| Format | application/pdf |
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