Charles University, Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Ondřej Kratochvíl Supervisor: prof. RNDr. Milan Pour, Ph.D. Supervisor - specialist: Mgr. Rastislav Antal Title of Thesis: Reduction of electron-deficient dendralenes by hydride reagents This diploma thesis is focused on the preparation of electron-deficient [3]dendralenes containing electron withdrawing groups such as carbonyl and ester functionalities. The synthesis is based on a palladium-catalyzed Migita-Stille coupling between stannylated diene and iodinated alkene (cycloalkene). Subsequent reaction of these substituted [3]dendralenes with hydride anion leads to a 1,2- or 1,4-addition to the α, β-unsaturated carbonyl group, resulting in the formation of an enolate or alcoholate, which are further transformed to various products depending on the type of the [3]dendralene.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:453218 |
| Date | January 2021 |
| Creators | Kratochvíl, Ondřej |
| Contributors | Pour, Milan, Krátký, Martin |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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