Sonic hedgehog (Shh) signaling regulates important biological processes during embryogenesis and adult homeostasis. Deregulation of this essential signaling pathway can lead to congenital defects and tumorigenesis. In this dissertation I explored the functional role of the cholesterol modification on Shh protein during central nervous system (CNS) patterning, determined previously unappreciated regulation of Shh pathway on hindbrain choroid plexus and cerebellum development, and established a novel mouse model for cerebellar tumor, medulloblastoma. These findings provide us new knowledge of how Shh signaling regulates various CNS organ development, as well as novel insights into the oncogenic processes in Shh-dependent brain tumor.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03312010-132747 |
| Date | 17 May 2010 |
| Creators | Huang, Xi |
| Contributors | Vivien A. Casagrande, Ethan Lee, Michael K. Cooper, Chin Chiang |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu//available/etd-03312010-132747/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
Page generated in 0.0024 seconds