Recently, high carbohydrate diets were recommended for the
treatment of diabetes mellitus. All aspects of these diets, however,
have not been fully tested — particularly in insulin dependent
diabetes mellitus (IDDM). The present study was designed to
investigate the effects of high carbohydrate, low fat diets (HCLFD)
on blood glucose regulation, lipoprotein and apoprotein concentrations
and nutritional status in IDDM.
Six women with IDDM were studied in the Clinical Research Center
for ten weeks. The study was divided into a control diet (CD) with
45% CHO, 40% fat, and 15% protein for four weeks, and a HCLFD with
65% CHO, 20% fat, and 15% protein for six weeks. Subjects were allowed
free selection of their carbohydrate and fiber sources during both
diet periods. The resulting selections produced diets with
approximately equal proportions of complex and simple carbohydrates
(49% and 51%, respectively) and moderate quantities of dietary fiber
(50 g) during the HCLFD. Weekly fasting and pre-prandial serum glucose
and glycosylated hemoglobin, and daily 24 hr. urine glucose excretion
and insulin dose were not significantly different between the two
periods. Total plasma, LDL and HDL cholesterol concentrations (p<.05).
and apopproteins AI (p<.001), B (p<.01) and CIII (p<.05) were significantly
lower, VLDL cholesterol (p<.05), total plasma (p<.01) and
VLDL (p<.001) triglycerides were significantly higher, and apoproteins
AII and E were unchanged during the HCLFD. Lipoprotein and apoprotein
concentrations were independent of glycemic control. There were no
significant changes in any of the nutritional parameters tested. All
except vitamin B₆ were within their respective normal ranges. Whole
blood and plasma vitamin B₆, and pyridoxal 5'-phosphate fell below
the lower limits, even though dietary intakes were adequate.
The present study suggest that HCLFD did not adversely affect
glycemic control in IDDM, and demonstrated a potentially beneficial
lowering of total and LDL cholesterol concentrations independent of
glycemic control. Finally, nutritional status appeared unaltered as
a result of HCLFD. The lower levels of the B₆ vitamers in IDDM
demonstrated in this study suggest that the relationship between
diabetes and vitamin B₆ status needs to be investigated further. / Graduation date: 1982
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27482 |
| Date | 30 April 1982 |
| Creators | Hollenbeck, Clarie |
| Contributors | Leklem, James E. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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