The objective was to conduct a systematic review and meta-analysis of randomized feeding trials to assess the effect of dietary pulses (beans, chickpeas, lentils, peas) on established lipid targets of cardiovascular disease (CVD) and perform a secondary analysis of our randomized feeding trial to assess whether dietary pulses as a means of lowering the glycemic index offer further CVD protection by reducing oxidative stress. The meta-analysis of 26 trials (n=1013) found dietary pulse interventions significantly lowered LDL-C compared with isocaloric control interventions (mean difference=-0.17mmol/L [95% CI: -0.25, -0.09]; p<0.0001). No treatment effects were observed for Apo-B and non-HDL-C. Our feeding trial found no significant differences between the high-dietary pulse diet and high-fibre control diet on markers of oxidative stress, including thiobarbituric acid reactive substances (TBARS), conjugated dienes (CDs), and protein thiols. Overall, the results suggest dietary pulses reduce LDL-C but not oxidative stress as a means of reducing cardiovascular risk.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/42859 |
| Date | 26 November 2013 |
| Creators | Ha, Vanessa |
| Contributors | Jenkins, David J. A., Sievenpiper, John L. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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