Purpose: To investigate if apparent diffusion coefficient (ADC) values within primary central nervous system lymphoma correlate with cellularity and proliferative activity in corresponding histological samples.
Materials and Methods: Echo-planar diffusion-weighted magnetic resonance images obtained from 21 patients with primary central nervous system lymphoma were reviewed retrospectively. Regions of interest were drawn on ADC maps corresponding to the contrast enhancing parts of the tumors. Biopsies from all 21 patients were histologically analyzed. Nuclei count, total nuclei area and average nuclei area were measured. The proliferation index was estimated as Ki-67 positive nuclei divided by total number of nuclei. Correlations of ADC values and histopathologic parameters were determined statistically. Results: Ki-67 staining revealed a statistically significant correlation with ADCmin (r = -0.454, p = 0.038), ADCmean (r = -0.546, p = 0.010) and ADCmax (r = -0.515, p = 0.017). Furthermore, ADCmean correlated in a statistically significant manner with total nucleic area (r = -0.500, p = 0.021). Conclusion: Low ADCmin, ADCmean and ADCmax values reflect a high proliferative activity of primary cental nervous system lymphoma. Low ADCmean values—in concordance with several
previously published studies—indicate an increased cellularity within the tumor.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-210909 |
| Date | 22 September 2016 |
| Creators | Schob, Stefan, Meyer, Jonas, Gawlitza, Matthias, Frydrychowicz, Clara, Müller, Wolf, Preuss, Matthias, Bure, Lionel, Quäschling, Ulf, Hoffmann, Karl-Titus, Surov, Alexey |
| Contributors | Universität Leipzig, Medizinische Fakultät, Universität Leipzig, Medizinische Fakultät, Universität Leipzig, Medizinische Fakultät, Martin-Luther-Universität, Universitätsklinikum, Universität Leipzig, Medizinische Fakultät, McGill University, Health Centre, Montreal General Hospital,, Public Library of Science, |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article |
| Format | application/pdf |
| Source | PLoS ONE 11(8): e0161386. doi:10.1371/journal.pone.0161386 |
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