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Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study

The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:24909
Date26 September 2006
CreatorsSarkar, Indrani
ContributorsBuchholz, Frank, Stewart, Francis, Hauber, Joachim
PublisherTechnische Universität Dresden
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess

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