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Previous issue date: 2016-02-23 / Marcadores biológicos são requeridos para estimar o risco de recorrência da doença em
mulheres com câncer de mama. O Ki67 é um marcador de proliferação celular e seu valor
preditivo e prognóstico tem sido estudado como um importante biomarcador de rotina na
prática clínica. Nosso estudo teve como objetivo avaliar a relação entre a intensidade da
expressão do Ki-67 e o envolvimento de linfonodos axilares com metástases com a sobrevida
livre de doença em mulheres com câncer de mama. Esse estudo foi retrospectivo e 134
pacientes foram elegíveis para o estudo. A associação entre os escores do Ki67 e outros
fatores prognósticos, tais como tamanho do tumor, grau, status dos linfonodos axilares,
invasão perineural e linfovascular, biomarcadores RE, RPg e HER-2 foram avaliados, além da
análise de sobrevivência. Dos 134 pacientes, 53 tiveram recorrência da doença. O valor da
mediana dos escores do Ki67 foi de 30% de todos os pacientes. Um total de 78 (58,25) dos
pacientes tiverm escores alto do Ki67. A associação estatisticamente significante foi entre os
escores altos do Ki67 com o grau histológico (p<0.001), subtipos moleculares (p<0.001),
receptores de estrógeno (p=0.023) e receptores de progesterona (p=0.001). A sobrevida livre
de doença em indivíduos com Ki67 alto e axila clinicamente negativa apresentou um menor
tempo em meses em comparação com os indivíduos com escores do Ki67 baixo (p=0.049). / Biological markers are required to estimate the risk of disease recurrence in women with
breast cancer. The Ki 67 is a cell proliferation marker and its predictive and prognostic value
has been studied as an important marker in routine clinical practice. Our study aimed to
evaluate the relationship between the intensity of Ki67 expression and involvement of axillary
lymph nodes with metastases to the disease-free survival in women with breast cancer. This
was a retrospective study and 134 patients were eligible for the study. The association
between the scores of Ki67 and other prognostic factors such as tumor size, grade, status of
axillary lymph nodes, perineural invasion and lymphovascular, in addition to biomarkers ER,
PgR, and HER2 were evaluated, as well as survival analysis. Of the 134 patients, 53 have had
recurrence of disease. The median value of Ki scores 67 was 30% of all patients. A total of 78
(58.25) of the patients had high scores Ki 67. A statistically significant association was
between high scores of Ki67 with the histological grade, molecular subtypes of progesterone
receptors estrogen receptors. A statistically significant association was between high scores of
Ki67 with the histological grade (p <0.001), molecular subtypes (p <0.001), estrogen receptor
(p = 0.023) and progesterone receptors (p = 0.001). The disease-free survival in patients with
high Ki67 and clinically negative axilla had a shorter time in months compared to individuals
with low Ki67 scores (p = 0.049).
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufpe.br:123456789/20411 |
| Date | 23 February 2016 |
| Creators | PAIVA, Carina Batista |
| Contributors | http://lattes.cnpq.br/3102982146162300, MEDEIROS, Paloma Lys de, CARVALHO, Paulo Roberto Cavalcanti |
| Publisher | Universidade Federal de Pernambuco, Programa de Pos Graduacao em Patologia, UFPE, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFPE, instname:Universidade Federal de Pernambuco, instacron:UFPE |
| Rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil, http://creativecommons.org/licenses/by-nc-nd/3.0/br/, info:eu-repo/semantics/openAccess |
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