<p>Intracellular motions are important signatures of living
tissues, and intracellular dynamics reflect overall cell function and health.
Traditional microscopy methods can track 2D cellular motions but do not provide
an ensemble evaluation of intracellular activity. Biodynamic imaging (BDI) is a
unique 3D imaging technique based on the phase shifts of dynamic light
scattering and is highly sensitive to intracellular dynamics in living cells
and their changes. This makes BDI a versatile tool to evaluate many different
types of samples under various scenarios, and BDI has the potential to improve
patient diagnosis and to provide valuable information for health care research.
This may include evaluating sample activity, profiling patient chemotherapy
response, and studying drug mechanisms. This thesis discusses the theory and modeling
of BDI, the construction of BDI systems, sample heterogeneity analysis (TDSI),
and the use of BDI to study cytoskeletal drug mechanisms, improve embryo
selection and select therapies in pre-clinical trials.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/12269291 |
| Date | 08 May 2020 |
| Creators | Zhe Li (8812511) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Doppler_Fluctuation_Spectroscopy_in_Living_Tissues/12269291 |
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