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Building Carbohydrates on Dioxanone Scaffold

Protected DHA units, known as dioxanones, are interesting compound which can be
used as the building blocks for synthesis of polyoxygenated natural products. The direct aldol reaction is employed for converting of those inexpensive starting materials into enantioenriched products of complexed structures. The stereocontrol in the first aldol reaction is achieved by using organocatalysis. Second aldol reaction is conducted by lithium enolate chemistry leading to anticisanti aldols as a major isomer. On the other hand boron chemistry provides antitransanti products. This strategy is used for synthesis of higher sugars.

Identiferoai:union.ndltd.org:USASK/oai:usask.ca:etd-01052009-081904
Date12 January 2009
CreatorsNiewczas, Izabella Sylwia
ContributorsKraatz, Heinz-Bernhard, Foley, Steven, Palmer, David, Grochulski, Pawel, Majewski, Marek
PublisherUniversity of Saskatchewan
Source SetsUniversity of Saskatchewan Library
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://library.usask.ca/theses/available/etd-01052009-081904/
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