Proper functioning of instruments requires precise calibration and routine quality assurance. In a clinical setting, this is achieved through the use of phantoms, which mimic the physical characteristics of tissues. Polyvinyl alcohol (PVA), a non-toxic, water-soluble polymer is well-suited for use as clinical phantom material. Through successive freezing and thawing, solutions of PVA in water can be solidified into rigid cryogels (PVA-C). The number of freeze-thaw cycles affects the properties of the material, including its optical characteristics.
A double integrating sphere system was used in conjunction with the Inverse Adding Doubling (IAD) algorithm to characterize the optical properties of thin slab samples. The setup was evaluated using liquid phantoms. Liquid emulsion and food colouring were used to impart scattering and absorbing properties in the range characteristic of human tissue. Measured values of normalized reflectances and transmittances were entered into IAD, and a set of optical properties (μ′s,μa,g) retrieved. The reduced scattering coefficient was found to increase linearly with increasing lipid concentration, while a consistent overestimation of the absorption coefficient was observed.
Measurements of PVA cryogels revealed a linear increase in the reduced scattering coefficient with an increasing number of freeze-thaw cycles up to five cycles. Scattering was also observed to increase with concentration up to PVA concentrations of 15%, and to spontaneously increase during the lifetime of the slab samples. These findings suggest it is possible to tune the optical scattering of PVA-C via different purely physical mechanisms. / Thesis / Master of Science (MSc)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/16669 |
| Date | 26 January 2015 |
| Creators | Fiee, Peter Q |
| Contributors | Diamond, Kevin R, Medical Physics |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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