The diploma´s thesis “Antitumor activity and targeted transport of rutin” deals with the effect of flavonoid rutin on tumor and non-tumor cells. The thesis is divided into the theoretical part and practical part. The theoretical part deals with rutin itself, tumor diseases and nanocarrier apoferritin. The practical part has three main parts. The first one deals with the properties of the rutin itself, its stability for storage and stability in solutions simulating distinct physiological environments. Furthermore, toxicity of rutin for tumor and non-tumor cells and the effect on the expression of proteins involved in the malignant potential of tumor cells were investigated. The second part deals with encapsulation of rutin into apoferritin (to form aporutin), characterization of this complex by means of its stability and toxicity for tumor and non-tumor cells. The third and last part focuses on a combined therapy in terms, of the synergistic action of rutin/aporutin together with doxorubicin on tumor and non-tumor cells was investigated.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:427862 |
| Date | January 2019 |
| Creators | Durďáková, Michaela |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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