Return to search

Identification and initial characterization of the Drosophila melanogaster clk-1 gene

The clk-1 gene was found in the screen for the maternal effect viable mutants in Caenorhabditis elegans. It is believed to be involved in controlling timing of various biological processes in the nematode including lengthening it's life span, and, as such, it belongs to the Clock group of genes. The CLK-1 homologue in yeast, COQ7, was shown to be involved in ubiquinone biosynthesis and gluconeogenic gene activation. The Drosophila clk-1 gene has been cloned. As a means to assay probable correlation between the timing mechanism of clk-1 and the circadian clocks, well studied in Drosophila, the clk-1 circadian mRNA expression has been monitored. At the middle of the dark phase, the level of clk-1 transcript decreases by approximately 30%. The Drosophila clk-1 mRNA expression during developmental stages was also analyzed. The amount of clk-1 mRNA is doubled during the larvae stage, the most metabolically active stage in the early Drosophila development.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.30685
Date January 2000
CreatorsLevina, Antonina.
ContributorsHekimi, S. (advisor), Pollack, G. (advisor)
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (Department of Biology.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 001763817, proquestno: MQ64389, Theses scanned by UMI/ProQuest.

Page generated in 0.0018 seconds