Sox proteins all contain a single ~70 amino acid High Mobility Group (HMG)
DNA-binding domain with strong homology to that of Sry, the mammalian testisdetermining
factor. In Drosophila melanogaster, there are four closely related members
of the B group, Dichaete (D), Sox Neuro (Sox N), Sox 21a, and Sox 21b that each exhibit
~90% sequence identity within the HMG domain.The previous study has shown that
Dichaete plays a major role in embryonic nervous system development and is expressed
in several clusters of neurons in the brain, including intermingled olfactory LNs and
central-complex neurons strongly expressed in local interneuron of the olfactory system.
However, little is known about the possible expression and functions of the related group
B Sox genes in the larval and adult brain. In particular, it is unclear if Sox N may
function along with Dichaete in controlling the development or physiology of the adult
olfactory system. Our data suggests Sox N potential role in the elaboration of the
olfactory circuit formation. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2017. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_38054 |
| Contributors | Singh, Shweta (author), Dawson-Scully, Ken (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 129 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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