This work was performed as a preliminary transdermal drug delivery (TDD) study to investigate the diffusion characteristics and effects of skin surfactants in vitro of four active ingredients on a poly(dimethyl siloxane) polycarbonate copolymer membrane. A Franz-type diffusion cell and various receptor solutions were used. The adhesive used was comprised of a polyisobutylene-based pressure sensitive adhesive manufactured by Adhesives Research Inc. High performance liquid chromatography was used to analyze the diffusion characteristics of these systems. In addition, the effects of two skin surfactants (sodium lauryl sulfate and dimethyl sulfoxide) on the adhesive were also investigated. Results from peel testing and thermal analysis showed that the peel strength, glass transition, and softening temperature of the adhesive was greatly reduced with the addition of the surfactants. / Master of Engineering
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/37141 |
| Date | 27 September 2001 |
| Creators | Trenor, Scott Russell |
| Contributors | Materials Science and Engineering, Love, Brian J., Corcoran, Sean Gerald, Kander, Ronald G. |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Detected Language | English |
| Type | Master's project |
| Format | application/pdf, application/pdf |
| Rights | I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
| Relation | MEng_Report.pdf, Vita.pdf |
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