This research work involves multifunctional magnetically targeted drug delivery
microspheres for treatment against breast cancer. A combination therapy approach was followed
by encapsulating two chemotherapeutics, 5-Fluorouracil (5-Fu) and cyclophosphamide in
poly(D, L-lactide-co-glycolide) (PLGA) microspheres. Magnetite nanoparticles and albumin
were also incorporated in the microspheres to achieve targeted treatment. The microspheres were
fabricated using oil-in-oil emulsion/solvent evaporation technique. Albumin is attracted to cancer
cells and thus it is likely to draw the microspheres towards tumor cells. On application of
magnetic field near tumor site, magnetites in the microspheres are likely to guide them to the
region of magnetic field. This will allow release of drugs from microspheres in the cancer cells.
Also the burst release of drugs and then slow release due to diffusion in the cancer cells lead to
effective treatment and also limit excessive spreading of drugs in other regions of the body.
Release rate study was carried out using high performance liquid chromatography (HPLC). Invitro
and in-vivo study was carried out to check the efficacy of treatment. / Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering.
| Identifer | oai:union.ndltd.org:WICHITA/oai:soar.wichita.edu:10057/5054 |
| Date | 07 1900 |
| Creators | Abedin, Farhana |
| Contributors | Asmatulu, Ramazan |
| Publisher | Wichita State University |
| Source Sets | Wichita State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Format | xix, 99 p. |
| Rights | © Copyright 2011 by Farhana Abedin. All rights reserved |
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