Doctor Pharmaceuticae - Dpharm / Among neurological disorders, many of the most devastating disorders are
neurodegenerative. Modern research associates excitotoxicity to a variety of
neuropathological conditions, suggesting that the neurodegenerative diseases with
distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity
occurs through over-stimulation of receptors for excitatory neurotransmitters like
the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA
receptors and excitotoxic processes, the antagonism or modulation of NMDA
receptors is used as a therapeutic tool against neurodegenerative diseases. NMDA
receptor activity can be modulated by S-nitrosylation and this modulation of
NMDA receptor activity can be utilised in the development of neuroprotective
drugs.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/6228 |
| Date | January 2017 |
| Creators | Sharma, Rajan |
| Contributors | Malan, Sarel F., Joubert, Jacques |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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