Return to search

The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism / Janet K. Coller.

Amendements: leaves 252-254. / Copies of author's previously published articles inserted. / Bibliography: leaves 226-251. / vi, 254 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil. / Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2000

Identiferoai:union.ndltd.org:ADTP/260834
Date January 1999
CreatorsColler, Janet K.
Source SetsAustraliasian Digital Theses Program
Languageen_US
Detected LanguageEnglish

Page generated in 0.0018 seconds