Return to search

Analýza genomu volně žijící améby Mastigamoeba balamuthi a porovnání s patogenní amébou Entamoeba histolytica / Analysis of the genome of a free-living amoeba Mastigamoeba balamuthi and its comparison with pathogenic Entamoeba histolytica

Charles University, Faculty of Science Department of parasitology Doctoral study programme: Parasitology Abstract (en) Analysis of the genome of a free-living amoeba Mastigamoeba balamuthi and its comparison with pathogenic Entamoeba histolytica Mgr. Vojtěch Žárský Supervisor: prof. RNDr. Jan Tachezy, Ph.D. Praha, 2020 Abstract Examination and comparison of organisms have been tremendously important for the study of life's history on earth. The progress of our understanding of the genetic basis of heredity and the recent boom of sequencing technologies allows us to continue in this exciting field of research from the perspective of genes and genomes. In this work, I focus on the study of an anaerobic amoeba Mastigamoeba balamuthi, which is related to an important human pathogen Entamoeba histolytica. Comparative analysis allows us to draw some conclusions about the nature of the common ancestor of Mastigamoeba and E. histolytica, how it adapted to the anaerobic lifestyle, and about the way the Entamoeba lineage evolved to become a successful parasite. Surprisingly we also noticed that besides hydrogenosomes (hydrogen-producing organelles related to mitochondria), M. balamuthi also harbors peroxisomes - organelles thought to be absent in anaerobic organisms. This finding motivated us to inquire more about...

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:415875
Date January 2020
CreatorsŽárský, Vojtěch
ContributorsTachezy, Jan, Bruchhaus, Iris, Beneš, Vladimír
Source SetsCzech ETDs
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

Page generated in 0.0018 seconds