<p> Animal studies have shown that the tonotopic organization of the auditory cortex is not statically fixed, but can be remodeled by experience. The purpose of this study was to investigate whether or not frequency discrimination training can induce changes in the cortical representation of a selected frequency in humans. Six human subjects were trained for approximately 3 weeks to detect a change in pitch between two tones (40Hz amplitude modulated) using a standard frequency of 2040 Hz. Each subject was tested on his/her discriminative ability before and after training using three different standards (2040Hz, 1840Hz, and 2240Hz). EEG data were recorded both before and after training and changes in transient and steady-state responses were investigated. Behaviourally, every subject improved at the discrimination task using the trained frequency. However, only three subjects demonstrated transfer to both untrained frequencies. In the EEG data, the P2-Nl amplitude increased in five of the six subjects and the Nllatency decreased in all six for the 2040Hz set. These two findings were statistically significant (p<0.05) for the group. There were no statistically significant findings for the side frequencies. The change in the 40 Hz steady-state response was also not significant, increasing in three subjects and decreasing in the other three. These findings indicate that changes are expressed in the secondary auditory cortex. These findings may also be applicable to the treatment of tinnitus. </p> / Thesis / Master of Science (MSc)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/22642 |
| Date | 09 1900 |
| Creators | Eaton, Robert |
| Contributors | Roberts, L. E., Physics |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
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