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Study on the ion formation process(es) in matrix-assisted laser desorption/ionization mass spectrometry.

by King Lai Wong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 86-93). / Title Page --- p.i / Table of Contents --- p.ii / List of Tables --- p.iv / List of Figures --- p.v / Abbreviations --- p.viii / Acknowledgements --- p.ix / Abstract --- p.x / Chapter CHAPTER ONE --- INTRODUCTION / Chapter 1.1. --- Mass Spectrometry for Macromolecular Analysis --- p.1 / Chapter 1.2. --- Laser Desorption --- p.3 / Chapter 1.3. --- Development of Matrix-assisted Laser Desorption/Ionization (MALDI) --- p.4 / Chapter 1.4. --- Matrix-assisted Laser Desorption/Ionization --- p.5 / Chapter 1.4.1. --- Laser --- p.6 / Chapter 1.4.2. --- Matrix Selection --- p.6 / Chapter 1.4.3. --- Sample Preparation Methodology --- p.7 / Chapter 1.4.4. --- Ion Formation Process(es) --- p.7 / Chapter 1.4.4.1. --- Desorption --- p.8 / Chapter 1.4.4.2. --- Ionization --- p.9 / Chapter 1.5. --- Time-of-Flight Mass Spectrometry --- p.12 / Chapter 1.6. --- Outline of the Present Work --- p.16 / Chapter CHAPTER TWO --- INSTRUMENTATION AND EXPERIMENTAL / Chapter 2.1. --- Instrumentation --- p.17 / Chapter 2.1.1. --- Laser System --- p.17 / Chapter 2.1.2. --- Ion Source --- p.19 / Chapter 2.1.3. --- Reflector --- p.20 / Chapter 2.1.4. --- Detector --- p.20 / Chapter 2.2. --- Experimental --- p.21 / Chapter 2.2.1. --- Synthesis of nitroanthracene-d9 --- p.21 / Chapter 2.2.2. --- Sample Preparation --- p.22 / Chapter CHAPTER THREE --- STUDIES OF THE EFFECTS OF SOLUTION pH / Chapter 3.1. --- Introduction --- p.25 / Chapter 3.2. --- Sample Preparation --- p.26 / Chapter 3.3. --- Results and Discussion --- p.28 / Chapter 3.3.1. --- Effect of Bronsted Base (NaOH) --- p.28 / Chapter 3.3.2. --- Effect of Lewis Base (Imidazole) --- p.33 / Chapter 3.3.3. --- Effect of Salt Concentration --- p.40 / Chapter 3.4. --- Conclusions --- p.44 / Chapter CHAPTER FOUR --- PROTON SOURCES FOR ION GENERATION IN MALDI-MS / Chapter 4.1. --- Introduction --- p.46 / Chapter 4.2. --- Sample Preparation --- p.47 / Chapter 4.3. --- Results and Discussion --- p.49 / Chapter 4.4. --- Conclusions --- p.55 / Chapter CHAPTER FIVE --- CATIONIZATION PROCESSES IN MALDI-MS : ATTACHMENT OF DIVALENT AND TRIVALENT METAL IONS / Chapter 5.1. --- Introduction --- p.57 / Chapter 5.2. --- Sample Preparation --- p.58 / Chapter 5.3. --- Results and Discussion --- p.60 / Chapter 5.3.1. --- Protonation versus Cationization --- p.60 / Chapter 5.3.2. --- Attachment of Divalent and Trivalent Metal Ions --- p.63 / Chapter 5.4. --- Conclusions --- p.80 / Chapter CHAPTER SIX --- CONCLUDING REMARKS --- p.82 / REFERENCES --- p.86

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_322682
Date January 1997
ContributorsWong, King Lai., Chinese University of Hong Kong Graduate School. Division of Chemistry.
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, xi, 93 leaves : ill ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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