A total of 27 new enediyne analogs of combretastatin A-4 (CA-4), with different substituents (Cl, Br, OCH3, SCH3 or N(CH3)2 ) of the aryl A-ring, were designed, synthesized, and evaluated for their growth inhibition activity against human tumor cell lines. Among them, compound 14a showed most significant inhibition activity against Hep3B (0.22 £gM), A-549 (0.49 £gM) and MCF-7 (0.22 £gM), and these activities were greater than CA-4. The enediyne analog 14a may be consider as a new drug candidate worthy of further investigation and development as a potential antitumor agent.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0708111-165920 |
| Date | 08 July 2011 |
| Creators | Chen, Pei-chi |
| Contributors | Tzeng, Cherng-Chyi, Wu, Ming-Jung, Ong, Chi-Wi |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708111-165920 |
| Rights | not_available, Copyright information available at source archive |
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