Phase separated domains in multicomponent vesicles form spherical buds to reduce interfacial energy. We study the response of a multicomponent budded vesicle to an imposed shear flow with dissipative particle dynamics. We find that shear can either act to stretch the bud open or separate the bud from the vesicle, depending on bud orientation. We examine the interplay of interfacial tension, bending energy, and shear in determining the behavior of the vesicle, and provide criteria for the design of vesicles for controlled bud release.
The neck connecting the budded domain with the bulk vesicle assumes a catenoid shape to minimize bending energy. We model the mechanism for pinch-off of catenoid necks with continuum elastic theory and dissipative particle dynamics. We examine pore nucleation and growth driven by Gaussian energy, by the adhesion energy of an encapsulated particle, and by the line energy of an interface between two amphiphile species, aiming to provide principles for the design of vesicles for biomimetic phagocytosis.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-04192007-154131 |
| Date | 16 July 2007 |
| Creators | Uspal, William Eric |
| Contributors | Michael J. Fasolka, Chandralekha Singh, Anna C. Balazs, Adam K. Leibovich |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-04192007-154131/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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