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The neonatal methylome as a gatekeeper in the trajectory to childhood asthma

Asthma is a heterogeneous group of conditions that typically begin in early life and result in recurrent, reversible bronchial obstruction. The role played by epigenetic mechanisms in the pathogenesis of childhood asthma is understood only in part. Here we discuss asthma epigenetics within a developmental perspective based on our recent demonstration that the epigenetic trajectory to childhood asthma begins at birth. We next discuss how this trajectory may be affected by prenatal environmental exposures. Finally, we examine in vitro studies that model the impact of asthma-associated exposures on the epigenome. All of these studies specifically surveyed human DNA methylation and involved a genome-wide component. In combination, their results broaden our understanding of asthma pathogenesis and the role the methylome plays in this process.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/623627
Date04 1900
CreatorsDeVries, Avery, Vercelli, Donata
ContributorsGraduate Program in Cellular & Molecular Medicine, University of Arizona, Asthma & Airway Disease Research Center, University of Arizona, Arizona Center for the Biology of Complex Diseases, University of Arizona, Department of Cellular & Molecular Medicine, University of Arizona, The Bio5 Institute, University of Arizona, Graduate Program in Cellular & Molecular Medicine, University of Arizona, Tucson, AZ, USA, Asthma & Airway Disease Research Center, University of Arizona, Tucson, AZ, USA
PublisherFUTURE MEDICINE LTD
Source SetsUniversity of Arizona
LanguageEnglish
Detected LanguageEnglish
TypeArticle
Rights© 2017 Future Medicine Ltd
Relationhttp://www.futuremedicine.com/doi/10.2217/epi-2016-0149

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