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A proteomic approach to discovering novel anti-influenza mechanisms in primary human airway epithelial cells

The influenza virus has a large impact on global health; however, it is difficult to formulate vaccines and influenza therapies that are effective against influenza. The influenza virus mutates rapidly, has the ability to emerge as novel strains with pandemic potential and can quickly become resistant to any given drug. Therefore, the generation of novel anti-influenza therapeutics that are effective against multiple strains would be highly beneficial. To date, the majority of anti-influenza research has focused on targeting specific components of the virus in order to interfere with its replication. However, it has been proposed that host proteins and signaling pathways may be essential components to viral replication and could also become novel anti-influenza drug targets. Therefore, this study utilized a large proteomic screen to identify host proteins that were up- and down-regulated in response to influenza infection. Collectively, these proteins clustered into five specific cell pathways and processes including interferon signaling, purine metabolism, cell death, ubiquitin-like signaling and mitochondrial oxidoreductases. Overall, this project identified potential novel anti-influenza targets in primary airway epithelial cells. / May 2015

Identiferoai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/30400
Date January 2013
CreatorsKroeker, Andrea
ContributorsHalayko, Andrew (Physiology and Pathophysiology) Coombs, Kevin (Medical Microbiology), Nickerson, Peter (Immunology) Czybryt, Michael (Physiology and Pathophysiology) Dodd, Janice (Physiology and Pathophysiology) Mossman, Karen (McMaster University)
PublisherJournal of Proteomic Research
Source SetsUniversity of Manitoba Canada
Detected LanguageEnglish

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