A dissertation submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the
degree of Master of Science. / A member of the epidermal growth factor (EGF) family; transforming
growth factor alpha (TGF-a) shares significant homology with EGF and
binds to the EGF receptor (EGF-R). Like EGF TGF-a plays important
roles in normal physiological processes; but, as its name signifies, it has
potent transforming ability; often associated with autocrine stimulatory
mechanisms. The purpose of this study is to investigate a possible role
for TGF-a and its receptor in certam human oesophageal squamous cell
carcinoma (SCC) cell lines - namely, WHCO-I, -3 and -5. The wellstudied
A431 epidermoid. carcinoma cell line was used throughout for
control purposes. (Abbreviation abstract) / Andrew Chakane 2018
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/25852 |
| Date | January 1993 |
| Creators | Jones, Gregory Justin |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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