Osetljivost multiplo rezistentnih sojeva Acinetobacter baumannii na nekonvencionalne antimikrobne agense / Sensitivity of multi-drug resistant Acinetobacter baumannii strains to unconventional antimicrobial agents

Description

<p>U skladu sa postavljenim ciljevima rada formirana je kolekcija&nbsp;<br />fenotipski i genotipski okarakterisanih multiplo rezistentnih&nbsp;<br />kultura genomske vrste <em>Acinetobacter baumannii</em>. Za sojeve iz&nbsp;<br />kolekcije kultura utvrđen je anti-<em>A. baumannii</em> efekat etarskih&nbsp;<br />ulja, biljnih ekstrakata i njihovih bioaktivnih komponenti, kao&nbsp;<br />nekonvencionalnih antimikrobnih agensa. Takođe, osim njihovog&nbsp;<br />pojedinačnog efekta utvrđen je i kombinovani efekat&nbsp;<br />konvencionalnih i nekonvencionalnih antimikrobnih agenasa, koji&nbsp;<br />je dovedo do redukcije minimalnih ihnibitronih koncentracija oba&nbsp;<br />agensa u kombinaciji. Kombinacije etarskih ulja i njihovih&nbsp;<br />bioaktivnih komponenti sa trenutno dostupnim konvencionalnim&nbsp;<br />antibioticima, čija je efikasnost smanjena kada se primenjuju&nbsp;<br />pojedinačno, predstavljaju novu perspektivnu strategiju u terapiji&nbsp;<br />infekcija multiplo rezistentnim sojevima vrste <em>A. baumannii</em>.</p> / <p>In accordance to the aims of the work the collection of phenotypic and<br />genotypic characterized multidrug-resistant cultures of genomic species<br /><em>Acinetobacter baumannii</em> was formed. For the strains from the culture<br />collection an anti-<em>A. baumannii </em>effect of the essential oils, plant extracts<br />and their bioactive components, as non-conventional antimicrobial<br />agents, was determined. Also, in addition to their individual effect the<br />combined effect of conventional and non-conventional antimicrobial<br />agents was determined, which lead to a reduction of the minimal<br />inhibitroy cocnentrations of both agents in combination. Combinations<br />of the essential oils and their bioactive components with the currently<br />available conventional antibiotics, whose efficiency reduced when<br />administered individually, represent a promising new strategy for the<br />treatment of infections caused by multidrug-resistant <em>A. baumannii.</em></p>

Links & Downloads

1. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145873737975211.pdf?controlNumber=(BISIS)100328&fileName=145873737975211.pdf&id=5139&source=NDLTD&language=en
2. https://www.cris.uns.ac.rs/record.jsf?recordId=100328&source=NDLTD&language=en

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Additional Fields

Identifer	oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)100328
Date	30 May 2016
Creators	Aleksić Verica
Contributors	Knežević Petar, Mimica-Dukić Neda, Igić Ružica, Knežević-Vukčević Jelena
Publisher	Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad
Source Sets	University of Novi Sad
Language	Serbian
Detected Language	English
Type	PhD thesis