This study was designed to characterize the cardiac output (Q$ sb{ rm c}$) response to progressive submaximal upright (U) exercise in CF patients. Secondly, the Q$ sb{ rm c}$ adjustments were compared to those of similar supine (S) exercise, in an attempt to assess myocardial accommodation to the enhanced ventricular preload in the S posture. Q$ sb{ rm c}$ generally increased with exercise intensity in both U and S positions, although gr.IV plateaued at 50% VO$ sb2$max (S). Maximal stroke volume index (SI) was achieved at 50% VO$ sb2$max (U) in all groups, except gr.IV and at 30% VO$ sb2$max (S) in all groups. The change from U to S posture resulted in a significant (p $ le$.05) increase in SI at rest and for every submaximal exercise in gr.I, but not in CF patients, independent of disease severity eg(Rest:gr.I:27 $ pm$ 7(U) vs 39 $ pm$ 8(S); gr.II:24 $ pm$ 5vs28 $ pm$ 10; gr.III:18 $ pm$ 4 vs 22 $ pm$ 5; gr.IV:17 $ pm$ 4 vs 20 $ pm$ 6 ml/bt/m$ sp2$). These observations suggest a limitation in ventricular volume accommodation in CF patients which becomes apparent under the S exercise conditions.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.59255 |
| Date | January 1989 |
| Creators | Coughlan, Mary Louise |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Arts (Department of Physical Education.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001067247, proquestno: AAIMM63445, Theses scanned by UMI/ProQuest. |
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