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An investigation into the loss of preservatives from opthalmic solutions, during filtration sterilization

Most eye drops are dispensed in multi-dose containers, hence protection should be given against microbial contamination during use. To remain sterile during it's use, the solution should contain a preservative in such concentration so that it kills micro-organisms in a short time. It has been stated in the literature that the instillation of contaminated eye drops constitutes a greater danger than the intravenous injection of a contaminated solution since the cornea is nonvascular and lacks the normal antimicrobial defences of the blood stream. Amongst the preservatives used, those included in the official formulations for eye drops are Chlorhexidine Acetate, Phenyl Mercuric Nitrate, Benzalkonium Chloride, and to some extent Phenylethanol, which may be used in combination with Benzalkonium Chloride. The main purpose of this investigation has been to determine the adsorption of these preservatives by different filters during sterilization by filtration. Part 1, p. 2.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:rhodes/vital:3851
Date January 1970
CreatorsNaidoo, N T
PublisherRhodes University, Faculty of Science, Pharmacy
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeThesis, Masters, MSc
Format253 leaves, pdf
RightsNaidoo, N T

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