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Stochastic perturbation theory and its application to complex biological networks -- a quantification of systematic features of biological networks

The primary objective of this thesis is to make a quantitative study of complex biological networks. Our fundamental motivation is to obtain the statistical dependency between modules by injecting external noise. To accomplish this, a deep study of stochastic dynamical systems would be essential. The first chapter is about the stochastic dynamical system theory. The classical estimation of invariant measures of Fokker-Planck equations is improved by the level set method. Further, we develop a discrete Fokker-Planck-type equation to study the discrete stochastic dynamical systems. In the second part, we quantify systematic measures including degeneracy, complexity and robustness. We also provide a series of results on their properties and the connection between them. Then we apply our theory to the JAK-STAT signaling pathway network.

Identiferoai:union.ndltd.org:GATECH/oai:smartech.gatech.edu:1853/49013
Date08 July 2012
CreatorsLi, Yao
ContributorsYi, Yengfei
PublisherGeorgia Institute of Technology
Source SetsGeorgia Tech Electronic Thesis and Dissertation Archive
Languageen_US
Detected LanguageEnglish
TypeDissertation

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