Elevated levels of the cytokine interleukin-18 (IL-18) are found in many chronic inflammatory disorders, including inflammatory bowel disease (IBD). However, the role of IL-18 in mucosal immunity and inflammation is not well understood. At mucosal and environmental interfaces, Th17 cells have been shown to contribute to protection from pathogenic infection. In contrast, regulatory T (Treg) cells maintain intestinal homeostasis by preventing aberrant inflammatory responses to the resident microbiota. We demonstrate that under homeostatic conditions, colonic Th17 cells highly express IL-18 receptor (IL-18R1) and that intestinal epithelial cell production of IL-18 acts directly on CD4<sup>+</sup> T cells to limit colonic Th17 differentiation. Furthermore, whilst IL-18R1-signalling is dispensable for induction of colitis, we observed a critical role for IL-18R1-signalling in Foxp3<sup>+</sup> Treg mediated control of colitis. Together, these studies demonstrate that the intestinal epithelium regulates colonic CD4<sup>+</sup> T cell responses through production of the cytokine IL-18.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:588471 |
| Date | January 2013 |
| Creators | Harrison, Oliver J. |
| Contributors | Maloy, Kevin J. ; Klenerman, Paul |
| Publisher | University of Oxford |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://ora.ox.ac.uk/objects/uuid:adcd849b-6a08-4ba9-b7db-0743a29cb377 |
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