Evidence obta1ned by various assay techniques has demonstrated that the plasma insulin level in maturity-onset diabetes is either normal or elevated (l, 2). Since pat1ents suffering from this disease also exhibit diminished responsiveness to the effects of exogenous 1nsul1n (3), their condition appears to be attributed to either failure of the target tissues to respond adequately to the hormone, or lack of metabolically active insulin. Recent investigations have established that insulin exerts a dual action on the glucose metabolism of mammals in vivo, decreasing the blood sugar both by inhibiting hepatic glucose production and by enhancing peripheral glucose utilization (4-9). Insulin unresponsiveness may be due to a failure of one or both of these actions. The localization of the defect in glucose metabolism is essential in fully understanding and correcting the impaired metabolism of the maturity-onset diabetic. Current evidence also indicates that an increase in plasma free fatty acid (FFA) concentration precedes other metabolic changes in maturity-onset diabetes (10, 11). FFA are released into the plasma by the adipose tissue (12). A widely-accepted hypothesis postulates a causal and inverse relationship between glucose uptake and FFA release by the adipose tissue. [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.72428 |
| Date | January 1965 |
| Creators | Csorba, Thomas Robert. |
| Contributors | Kalant, N. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Investigative Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001832354, proquestno: AAINK00439, Theses scanned by UMI/ProQuest. |
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