Yes / Polymer coatings that support epithelial cell culture have been developed. Ozonolysis and subsequent work up of poly(butyl methacrylate-co-butadiene) copolymers is used to form oligomers with carboxylic acid end groups, which are then further reacted with diamines to provide poly(butyl methacrylate)s with primary amine end groups. The polymers are cast as films and used as cell culture substrates for human dermal fibroblasts and human renal epithelial cells. Fibroblast and epithelial cells adhere and proliferate on acid functional materials but on amine functional films epithelial cells show greater viability than fibroblasts.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11542 |
| Date | 08 February 2017 |
| Creators | Cox-Nowak, K., Al-Yamani, Ohood, Grant, Colin A., Green, N.H., Rimmer, Stephen |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | (c) 2017 Taylor and Francis. This is an author's original manuscript of an article published by Taylor and Francis in the International Journal of Polymeric Materials and Polymeric Biomaterials in 2017. |
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