Obesity is considered an underlying risk factor for metabolic disease including cardiovascular disease (CVD) and diabetes. The fractions containing flavonols from apple peel were evaluated for their antioxidant, anti-inflammatory, and hypolipidemic properties using in vitro and in vivo experimental model systems. The fractionated polyphenolics from apple peels showed a strong antioxidant property protecting against heat-induced oxidation of polyunsaturated fatty acids present in fish oil. Apple flavonols (AF), eicosapentaenoic acid (EPA) and the isoquercitrin-EPA ester (QE) significantly reduced serum triacylglycerols and elevated the high density lipoprotein (HDL)-cholesterol compared to the high fat control group. C-reactive protein and interleukin-6 were also reduced compared to the high fat control group and inflammation induced by lipopolysaccharides. Serum adiponectin and interferon-? concentrations were significantly altered by QE treatment. Overall, AF and QE exhibited anti-inflammatory and hypolipidemic effects under in vivo conditions. These beneficial physiological properties and mode of action of AF and QE need to be further investigated.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/15469 |
| Date | 23 August 2012 |
| Creators | Sekhon-Loodu, Satvir |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
Page generated in 0.0015 seconds