Return to search

Expression of interleukin-6 (IL-6) in the cerebellum is not altered in the absence of Fragile X Mental Retardation Protein (FMRP) or with motor skill learning

The ability of the brain to change structurally and functionally with experience is called brain plasticity. High levels of pro-inflammatory cytokines impair normal memory formation and consolidation. To better understand the role of pro-inflammatory cytokines in learning, the contribution of the cytokine interleukin-6 (IL-6) to a motor skill learning task investigated. The Fmr1 Knockout (KO) mouse, an animal model of Fragile X Syndrome, has demonstrated impaired neural plasticity and learning. Fmr1 KO and control wild-type (WT) mice were trained on the dowel and flat beam runways to study motor skill learning and motor activity respectively. The cerebellum from the animals was examined for IL-6 protein using ELISA. No significant differences in the levels of IL-6 in the cerebellum of the Fmr1 KO and WT normal mice were found. The expression of IL-6 was not altered by the behavioural training. These results suggest lack of association between IL-6, and FMRP and motor skill learning. / October 2016

Identiferoai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/31638
Date06 September 2016
CreatorsTabatabaei, Dina
ContributorsIvanco, Tammy (Psychology), Montgomery, Janine (Psychology) Marzban, Hassan (Human Anatomy and Cell Science)
Source SetsUniversity of Manitoba Canada
Detected LanguageEnglish

Page generated in 0.0017 seconds