Salt iodization is widely available throughout the developing world. Incorporating other micronutrients into the existing salt iodization process could prevent multiple deficiencies.
The thesis objective was to develop a stable formulation of salt dual fortified with folic acid and iodine, using a single solution that could be sprayed on. The micronutrients needed to be fully solubilized and stable in solution for at least one month. In the absence of an alkaline environment or antioxidant, iodine losses occur most likely due to the oxidation of folic acid by potassium iodate.
Optimal salt formulations were prepared by spraying a pH 9 carbonate-bicarbonate buffer solution containing folic acid and iodine dissolved at 0.35% (w/v) each. Acceptable micronutrient retentions of > 90% were observed in refined salt after 6 months of storage at 45°C/60% relative humidity.
Further investigations into increasing the concentration of iodine and folic acid in the spray solution are recommended.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/31430 |
| Date | 20 December 2011 |
| Creators | Sangakkara, Angjalie Ruwanika |
| Contributors | Diosady, Levente L. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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