Chung, Shu Lu. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 109-118). / Abstracts in English and Chinese. / Abstract --- p.i-iv / 中文摘要 --- p.v-vii / Publications --- p.viii / Acknowledgements --- p.ix / List of Abbreviations --- p.x-xi / Index for Figures --- p.xii-xiv / Index for Tables --- p.xv / Table of Contents --- p.xvi-xix / Chapter Session 1: --- Introduction --- p.1 / Chapter 1.1 --- Biology of fracture healing process --- p.2 / Chapter 1.1.1 --- Stage of inflammation --- p.2-3 / Chapter 1.1.2 --- Stage of soft callus formation --- p.3-4 / Chapter 1.1.3 --- Stage of hard callus formation --- p.4-5 / Chapter 1.1.4 --- Stage of bone remodeling --- p.5 / Chapter 1.2 --- Conventional treatments and its limitations --- p.5-6 / Chapter 1.3 --- Biological treatments in accelerating fracture healing process --- p.6-7 / Chapter 1.4 --- Biophysical treatments in accelerating fracture healing process --- p.7-8 / Chapter 1.4.1 --- Electromagnetic fields --- p.8-9 / Chapter 1.4.2 --- Shockwave --- p.9 / Chapter 1.4.3 --- Low intensity pulsed ultrasound --- p.9-11 / Chapter 1.5 --- Properties of ultrasound --- p.11 / Chapter 1.5.1 --- Ultrasound signals --- p.11-12 / Chapter 1.5.2 --- Attenuation of ultrasound --- p.12-14 / Chapter 1.5.3 --- Modes of ultrasound wave propagation --- p.14-15 / Chapter 1.5.4 --- Reflection and critical angle --- p.15-18 / Chapter 1.6 --- Insights from previous studies --- p.18-19 / Chapter 1.7 --- Hypothesis --- p.19 / Chapter 1.8 --- Study plan --- p.20 / Chapter 1.9 --- Objectives --- p.20 / Chapter Session 2: --- Materials and Methodology --- p.25 / Chapter 2.1 --- Materials --- p.26 / Chapter 2.2. --- Closed femoral fracture rat model --- p.26 / Chapter 2.2.1 --- Operation procedures --- p.26-27 / Chapter 2.3 --- Groupings --- p.27 / Chapter 2.4 --- Low Iintensity Pulsed Ultrasound treatment --- p.28 / Chapter 2.4.1 --- Incident angles determination --- p.28 / Chapter 2.4.2 --- LIPUS devices --- p.29 / Chapter 2.4.2 --- Set up of standardized platform --- p.29-30 / Chapter 2.4.4 --- Treatment procedure --- p.30 / Chapter 2.5 --- Radiographic analysis --- p.31 / Chapter 2.6 --- Micro-Computed Tomography --- p.32 / Chapter 2.6.1 --- Micro-Computed Tomography scanning --- p.32 / Chapter 2.6.2 --- Micro-Computed Tomography analysis --- p.32-33 / Chapter 2.7 --- Histology --- p.34 / Chapter 2.7.1 --- Sample preparation --- p.34 / Chapter 2.7.2 --- Histomorphometrical analysis --- p.34-35 / Chapter 2.8 --- Mechanical Testing --- p.35 / Chapter 2.9 --- Statistical analysis --- p.35 / Chapter Session 3: --- Results --- p.48 / Chapter 3.1 --- Radiographic analysis --- p.49 / Chapter 3.1.1 --- Qualitative analysis - Callus bridging rate --- p.49 / Chapter 3.1.2 --- Quantitative analysis - Callus area and callus width --- p.49-50 / Chapter 3.2 --- Micro-computed tomography analysis --- p.50 / Chapter 3.2.1 --- Qualitative analysis - 3D reconstructed images --- p.50-51 / Chapter 3.2.2 --- Quantitative analysis - Bone volume of callus --- p.51 / Chapter 3.2.3 --- Quantitative analysis - Bone mineral density and bone mineral content --- p.51-52 / Chapter 3.3 --- Biomechanical test --- p.52-53 / Chapter 3.4 --- Histomorphological analysis --- p.53 / Chapter 3.4.1 --- Qualitative analysis --- p.53 / Chapter 3.4.2 --- Quantitative analysis --- p.53-54 / Chapter Session 4: --- Discussion --- p.85-87 / Chapter 4.1 --- Enhancement effects of LIPUS at different incident angles --- p.88 / Chapter 4.1.1 --- LIPUS transmitted at 350 accelerated the fracture healing process --- p.88 / Chapter 4.1.1.1 --- Callus bridging and callus mineralization --- p.88-89 / Chapter 4.1.1.2 --- Dose dependent effects of LIPUS -Maximization of ultrasound energy --- p.89-90 / Chapter 4.1.2 --- LIPUS transmitted at 35° enhanced the restoration of mechanical properties in fracture healing process --- p.90 / Chapter 4.1.2.1 --- Biomechanical properties --- p.90-91 / Chapter 4.1.2.2 --- Bone mineral density and bone mineral content --- p.91-92 / Chapter 4.1.2.3 --- Highly mineralized callus area and volume --- p.92-93 / Chapter 4.2 --- 35° may be the critical angle for further enhancing fracture healing --- p.93 / Chapter 4.2.1 --- LIPUS transmitted at 35° may be the first critical angle in this study --- p.93-95 / Chapter 4.2.2 --- Effects of different incident angles --- p.95-96 / Chapter 4.3 --- Mechanism of LIPUS at different incident angles on fracture healing process --- p.96 / Chapter 4.3.1 --- Endochondral ossification --- p.96-99 / Chapter 4.4 --- Advantages in using LIPUS transmitted at critical angle --- p.99 / Chapter 4.5 --- Limitations of the study --- p.100 / Chapter 4.5.1 --- Animal model --- p.100 / Chapter 4.5.2 --- Treatment sites of LIPUS transmitted at different incident angles --- p.100 / Chapter 4.5.3 --- Types of fracture --- p.101 / Chapter Session 5: --- Conclusions --- p.102-104 / Chapter Session 6: --- Future Studies --- p.105 / Chapter 6.1 --- Protocol and regime of LIPUS transmitted at different angles --- p.106 / Chapter 6.2 --- Periosteum-stripped fracture model --- p.106-107 / Chapter 6.3 --- Molecular mechanism of LIPUS transmitted at different incident angles --- p.107-108 / Bibliography --- p.109-118 / Appendix I --- p.119
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_326458 |
| Date | January 2008 |
| Contributors | Chung, Shu Lu., Chinese University of Hong Kong Graduate School. Division of Orthopaedics and Traumatology. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, xix, 119 leaves : ill. (some col.) ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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