For more than fifty years glucocorticoids (GCs) has been used to treat a
wide range of inflammatory diseases, such as allergies, asthma, rheumatoid
arthritis, and autoimmune diseases, due to its potentiality on the antiinflammatory
and immunomodulatory effects. The anti-inflammation actions
of glucocorticoid were mediated by an intracellular receptor, glucocorticoid
receptor (GR), a member of the nuclear receptor family of ligand-dependent
transcription factor. Upon activation by their ligand, GRs translocated to the
nuclear and then bound to glucocorticoid responsive element (GRE) or
negative glucocorticoid responsive elemen (nGRE). The administration of
GCs depended on the acuity of disease and on the responses of patient
clinically. Although some Systemic Lupus Erythematosus (SLE) patients
given the maximal steroid doses, the response to the therapy remained
poorly, and thus called ¡§glucocorticoid resistance¡¨. Despite the fact that the
side effects and complications in SLE patients may result from the
restrictions of physic; it has been documented that there were some
relationships between the glucocorticoid resistance with the polymorphisms
of GR, and the levels of glucocorticoid receptor beta. However, no
significant differences in the GR polymorphisns (TthIII, ER22/23EK, N363S,
BclI and I559N) between controls and SLE patients were found and there
were no significant differences found on the levels of SUMO-2 antibody
between patients with active and inactive SLE in this study. Neverthless, a
significant association on the the allelic polymorphism of BclI was observed
in patients with glucocorticoid resistance. Additionally, the expression of
GR£] in patients with SLE was higher than that of controls and the TthIII CT
genotype was associated with GR£\ expression.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0730108-135015 |
| Date | 30 July 2008 |
| Creators | Lee, Bi-yao |
| Contributors | Deng-Chyang Wu, Angela Chen, Hurng-Wern Huang |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015 |
| Rights | campus_withheld, Copyright information available at source archive |
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