To test the hypothesis that maternal glucose restriction (GR) would compromise small intestine (SI) growth and development, we used a diet induced model of IUGR. Pregnant rats and offspring were fed isoenergetic diets {0% (deficient), 12, 24% (restricted), 60% (adequate) glucose) from gestation day (gd) 0 through adolescence. SI tissue was collected at gd20, birth, 12--24h, postnatal day (pd) 7, 15, 21, 28, 35, 49 and in controls. GR affected pup weight at early timepoints, resulting in IUGR; beyond effects due to differences in body wt, GR compromised SI length at 12--24h and promoted SI growth during peak lactation (pd15; total and distal wts). Dietary glucose regulated in utero (gd20) expression of sodium-dependent glucose co-transporter (SGLT1) protein. Diet-induced precocious maturation of lactase and sucrase was observed in glucose deficient animals. In summary, there were periodic but no permanent effects of dietary glucose intake on gut growth and development.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.21501 |
| Date | January 1999 |
| Creators | Anderson, Susan A. |
| Contributors | Koski, K. G. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001657714, proquestno: MQ50707, Theses scanned by UMI/ProQuest. |
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