<p> Phylogenetic analysis of gene order data is a developing area, and many questions
on gene orders are still unresolved. In this project, we started from the OGRe
database, where we obtained the mitochondrial genome information (after some corrections),
designed a logarithm correction for breakpoint distance, applied distance
matrix methods to both breakpoint distance and the logarithm of breakpoint distance
for gene orders, and then focused on Arthropoda phylogeny We tried many phylogenetic
methods to infer Arthropod phylogeny; however, no method yielded a satisfying
result. We constructed an Arthropod phylogenetic tree based on both molecular and
morphological evidences. After we estimated the phylogenetic tree, we used maximum
likelihood methods to estimate branch lengths for tRNAs and proteins, calculated the
breakpoint numbers and inversion numbers for gene orders, and calculated the correlations
among these four measures. We found that: when gene order rearrangements
and mutations on sequences are small, the changes are independent, and, when the
rearrangements and mutations are large, the changes seem to be correlated. The
branch lengths in the tRNA and protein trees are highly correlated in low mutation
situations and less correlated when mutation rates are larger. </p> / Thesis / Master of Science (MSc)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/22446 |
| Date | 08 1900 |
| Creators | Xu, Wei |
| Contributors | Higgs, Paul, Physics and Astronomy |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
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