Lipedema may be considered a model for healthy expandability of
subcutaneous adipose tissue (SAT). This condition is characterized by the
disproportional and symmetrical SAT accumulation in the lower-body parts
and extremities, avoiding the abdominal area. There are no circulating
biomarkers facilitating the diagnosis of lipedema. We tested the hypothesis
that women living with lipedema present a distinct pattern of circulating
parameters compared to age- and BMI-matched women. In 26 women (Age
48.3 ± 13.9 years, BMI 32.6 ± 5.8 kg/m2; lipedema group: n=13; control group:
n=13), we assessed circulating parameters of glucose and lipid metabolism,
inflammation, oxidative stress, sex hormones and a proteomics panel. We find
that women with lipedema have better glucose metabolism regulation
represented by lower HbA1c (5.55 ± 0.62%) compared to controls (6.73 ±
0.85%; p<0.001); and higher adiponectin levels (lipedema: 4.69 ± 1.99 mmol/l;
control: 3.28 ± 1.00 mmol/l; p=0.038). Despite normal glycemic parameters,
women with lipedema have significantly higher levels of total cholesterol (5.84
± 0.70 mmol/L vs 4.55 ± 0.77 mmol/L in control; p<0.001), LDL-C (3.38 ± 0.68
mmol/L vs 2.38 ± 0.66 mmol/L in control; p=0.002), as well as higher
circulating inflammation (top 6 based on p-values: TNFSF14, CASP8, ENRAGE,
EIF4EBP1 , ADA, MCP-1) and oxidative stress markers
(malondialdehyde, superoxide dismutase and catalase). Our findings suggest
that the expected association between activation of inflammatory and
oxidative stress pathways and impaired glucose metabolism are
counterbalanced by protective factors in lipedema.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:92958 |
| Date | 07 August 2024 |
| Creators | Nono Nankam, Pamela A., Cornely, Manuel, Klöting, Nora, Blüher, Matthias |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1664-2392, 10.3389/fendo.2022.1000094 |
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