Glycogen levels were studied in 15 Sprague-Dawley adult male rats. Three aspects of glycogen metabolism were considered. First, the glycogen concentrations of normally innervated red (soleus) and white (gastrocnemius) muscles were compared. Second, the glycogen content of innervated red and white muscles were compared to chronically denervated red and white muscles. Third, the effect of insulin upon glycogen stores in innervated and chronically denervated red and white muscles was examined.Innervated white muscles had higher glycogen levels than innervated red muscles. However, chronic denervation resulted in statistically significant decreases in red and white muscle glycogen content. In addition, insulin markedly increased glycogen stores in innervated red muscles, but not in white muscles. Further, the increase in glycogen levels in red muscle caused by insulin was abolished in chronically denervated preparations.The results suggest that the effects of insulin on skeletal muscle glycogen stores could be related to trophic influences of motor nerves.Ball State UniversityMuncie, IN 47306
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/180463 |
| Date | 03 June 2011 |
| Creators | Miller, Allen L. |
| Contributors | Henzlik, Raymond E. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | vi, 75 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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