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Effects of Gold Sodium Thiomalate on Murine Spleen Cells

The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact spleen cells; whereas, at 0.5 pg Con A/ml, the macrophage depleted spleen cells were inhibited to a greater degree than the intact spleen cells. Addition of GST at intervals ranging from 0 to 48 hours indicated that inhibition occurred within 36 hours following mitogen stimulation. These results suggest that GST inhibits early events of lymphocyte activation by direct interaction with lymphocytes.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc500436
Date12 1900
CreatorsBrownback, Paul (Paul Eldon)
ContributorsMeasel, John William, Jr., Barrow, William W., Goven, Arthur James, 1950-
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvi, 71 leaves: ill., Text
RightsPublic, Brownback, Paul (Paul Eldon), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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