Human chorionic gonodotropin (HCG) affected in various ways cell cultures infected with strains of Rous sarcoma virus (RSV). The cell cultures studied were chick embryo fibroblasts (CEF), normal rat kidney cells infected with temperature-sensitive mutant (LA31-NRK) and a wild type RSV (B77-NRK). HCG increased the rate of transformation and viral titer of CEF cells infected with RSV, but not B77-NRK. HCG increased significantly transformation rates of LA31-NRK, only if the temperature sensitive transformation process was first delayed by incubation at non-permissive temperatures. It is suggested that some postinfective, pretransformational event(s) may operate before viralmediated transformation rates are increased by HCG.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc663771 |
| Date | 08 1900 |
| Creators | Mitchell, Monte Mark |
| Contributors | Chen, Young C., Johansson, Karl R. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | v, 57 leaves, Text |
| Rights | Public, Mitchell, Monte Mark, Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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