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HACE1, a Novel Repressor of RAR Transcriptional Activity

The biological activities of retinoic acid (RA) and its synthetic analogues are mediated through nuclear receptors, termed retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The transcriptional activity of RAR on target gene expression is achieved by its AF-1 domain and AF-2 domain. The function of AF-2 is known to be mediated by a number of coregulatory proteins. However the mechanism of AF-1 function is not well studied. We have hypothesized that the AF-1 function of RAR is regulated by specific interacting proteins. HACE1 was identified as an AF-1 domain interacting protein in a yeast two-hybrid screen. HACE1 interacts with RAR&beta<sub>3 / Microbiology and Immunology

Identiferoai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/3934
Date January 2009
CreatorsZhao, Jianhua
ContributorsSoprano, Kenneth J., Soprano, Dianne R., Tsygankov, Alexander Y., Long, Walter K.
PublisherTemple University. Libraries
Source SetsTemple University
LanguageEnglish
Detected LanguageEnglish
TypeThesis/Dissertation, Text
Format173 pages
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Relationhttp://dx.doi.org/10.34944/dspace/3916, Theses and Dissertations

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