Clinical and morphological investigations were carried out concerning the osseointegration of dental implants. A clinical evaluation of 1087 implants placed over a seven year time span revealed an osseointegration success rate of 96%. Studies indicated that, on average 8.7 months lapsed between implant insertion and prosthesis delivery. A technique was developed to evaluate the process of osseointegration with the light microscope (LM) and transmission electron microscope (TEM). A rat model was used and threaded implants were fabricated from solid commercially pure titanium. LM demonstrated osseointegration and a preservation of implant surface topography utilizing this technique. TEM analysis revealed an electron dense lamina-limitans like layer covered by an amorphous substance adjacent to the surface of the implant. $ sp3$H-proline was used to label seams of bone formation in order to evaluate the distribution and rate of formation of the new bone next to the metal implant. Bone appeared to grow from the old presurgical bone towards the implant with no apparent direct influence of the metal. A quail embryo model was developed to evaluate the effects of vascular occlusion on the formation of bone and to label epithelial blood vessels with iodinated transforming growth factor-beta 1 applied to the chorioallantoic membrane. These preliminary experiments demonstrated that surgical manipulation of the quail embryo was possible for the purposes of studying the process of osseointegration.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.39399 |
| Date | January 1992 |
| Creators | Clokie, Cameron M. L. (Cameron Malcolm Lang) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Faculty of Dentistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001305821, proquestno: NN80341, Theses scanned by UMI/ProQuest. |
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