Experimental investigations were carried out concerning the use of bovine bone (Unilab Surgibone) grafted in the tibiae of rats. The first experiment evaluated tissue response of bovine bone as an inlay graft and the second experiment as an onlay graft. Histological and morphometric analyses were performed in order to obtain baseline data on tissue response for future experiments using titanium implants with bovine bone grafts in this model. Light microscopy demonstrated rapid incorporation of the inlay graft by new bone, whereas, the onlay graft was mainly encapsulated by fibrous tissue. However, a residual increase in the thickness of the outer cortex of the tibiae was observed with onlay graft. From the results of this study it appeared that Unilab Surgibone was biocompatible and did not induce a foreign body reaction. Future investigations using titanium implants in combination with the bovine bone grafts appears to be possible especially if an inlay/onlay design is attempted.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.55515 |
| Date | January 1994 |
| Creators | Monaghan, Pierre |
| Contributors | Clokie, C. M. L. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Faculty of Dentistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001426042, proquestno: AAIMM00042, Theses scanned by UMI/ProQuest. |
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