The effect of one day and five day antibiotic administration for prophylaxis in orthognathic surgical procedures was compared. / A randomized double-blind clinical trial using placebo was conducted. Thirty patients were equally distributed between two groups. Each group received Penicillin G two million units intravenously pre-operatively, and one million units I.V. every three hours intraoperatively and three hours post-operatively. Group one then received Penicillin G, one million units I.V. every six hours for eight doses, then Penicillin V suspension 300 mg orally every six hours for eight doses. Group two received placebo in a similar dosing schedule. The wounds were inspected post-operatively for infection. / One patient out of fifteen in group one (2.2%) and nine patients out of fifteen (60%) in group two (placebo) became infected. The overall infection rate was 33.3%. There was a statistically significant difference in rates of infection between the two groups (p $<$ 0.01). Antibiotic prophylaxis for orthognathic surgical procedures should continue beyond the immediate post-operative period. Five days of antibiotic administration appears to provide adequate coverage.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.61326 |
| Date | January 1992 |
| Creators | Aiello, George A. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Faculty of Dentistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001305304, proquestno: AAIMM80343, Theses scanned by UMI/ProQuest. |
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