Objectives. This study was undertaken to evaluate whether the effects of hyperbaric oxygen (HBO) therapy could alter the critical size for spontaneous healing of a bone defect in the rabbit calvarial model. / Study design. An animal trial of 12 weeks duration was conducted using 20 New Zealand White rabbits, which were randomly divided into 2 groups of 10 animals each. Calvarial defects were created in the parietal bone of each animal bilaterally. Defects were critical sized, 15mm on one side and supra critical sized, 18mm on the contralateral side. Group 1 received 90 minutes HBO treatment sessions at 2.4 ATA per day for 20 consecutive days. Group 2 served as a control without any HBO treatment sessions. Five animals in each group were sacrificed at 6 and 12 weeks. Data analysis included qualitative assessment of the calvarial specimens, post sacrifice radiographs as well as histomorphometric analysis to compute the amount of regenerated bone within the defects. Two way ANOVA was used for statistical analysis. / Results. Both radiographic analysis and histomorphometric analysis demonstrated that HBO treated animals had significantly more new bone within defects compared with the control group. There was no statistically significant difference between the percentage of new bone forming in the 15mm and 18mm HBO treated defects. There was no difference between the 6 week and the 12 week HBO treated groups. / Conclusion. HBO is effective in enhancing the bone healing of full thickness critical sized as well as supra-critical sized defects in the rabbit calvarial model. Bone regeneration was significantly greater in the HBO treated animals regardless the defect size. HBO may have increased the diameter of the rabbit critical sized calvarial defect to more than 18mm.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.99186 |
| Date | January 2006 |
| Creators | Iera, Deborah. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Faculty of Dentistry.) |
| Rights | © Deborah Iera, 2006 |
| Relation | alephsysno: 002566741, proquestno: AAIMR28495, Theses scanned by UMI/ProQuest. |
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