Ten healthy eumenorrheic white females (26.4 $\pm$ 5.2 yrs) were studied during the regular menstrual cycle (25 to 37 days) to determine the effects of the different phases of the cycle on plasma lipid and lipoprotein concentrations. Three blood samples were collected throughout the phases of the menstrual cycle. The first blood sample was collected in the early follicular phase (days 4-7) after the onset of the menses; the second blood sample in the ovulatory phase (days 12-14) approximately 24-48 hrs after ovulation; and the third blood sample in the luteal phase (days 24-26) nearly 6-9 days after ovulation. A repeated measures MANOVA was utilized for the analysis of the data with Tukey post-hoc employed to locate significant differences between means. A significant increase (12.4% and 24.4%) in plasma total cholesterol levels and (20.2% and 30.9%) in LDL-C levels were demonstrated during the follicular phase compared to the ovulatory and luteal phases of the cycle, respectively. During the ovulatory phase of the cycle, total cholesterol levels also increased significantly (10.7%) relative to the luteal phase. In addition, during the follicular phase there was a significant increase in plasma levels of HDL-C (19.2%) and HDL$\sb3$-C (13.9%) compared to the luteal phase. Moreover, a significant increase (74.2%) in plasma HDL$\sb2$-C levels were demonstrated during the ovulatory phase versus the luteal phase. Furthermore, HDL-C levels were significantly higher (20.8%) during the ovulatory phase compared to the luteal phase. There were no statistically significant changes in plasma triglyceride concentrations among cycle phases. The results of this study suggest that the fluctuations in plasma lipid and lipoprotein concentrations throughout the different phases of the normal menstrual cycle seems of vital importance to define exact days and phases of the / cycle in which blood samples are to be collected for analyzing plasma lipid and lipoprotein levels in premenopausal women. / Source: Dissertation Abstracts International, Volume: 55-12, Section: B, page: 5292. / Major Professor: Robert Moffatt. / Thesis (Ph.D.)--The Florida State University, 1994.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_77317 |
| Contributors | Allaithy, Aziz A., Florida State University |
| Source Sets | Florida State University |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | 366 p. |
| Rights | On campus use only. |
| Relation | Dissertation Abstracts International |
Page generated in 0.0019 seconds